Automated titrations: the use of automated multiple flow injection analysis for the titration of discrete samples

Introduction In 1974 Fleet and Ho 1] successfully demonstrated an automated continuous flow titration system using a reagent gradient. This system had a throughput of only ten samples per hour, but it was significant since it demonstrated the principles for titration of discrete samples in continuously flowing streams. Nagy et al. [2,3 ]have also demonstrated a similar approach. In 1977, Ruzicka et al. [4] described the principles and an apparatus for the automated titration of manually